Objective: To investigate the influence of N aosaitong (NST) on the cerebral blood flow (CBF), the infarct areas and blood
rh eology in animals. Method: NST's cerebral protective effec ts were investigated by using middle cerebral artery occlusion(MCAO), bilateral common carotid artery ligation, and carrogeenin-induced thrombus model rats, be ing administrated with medicine for seven days. Result: Th ree dosage groups of NST increased CBF in anesthetized rabbits, reduced the inf arct areas in MCAO rats, decreased the physical sign indexes, and water quantiti es. They inceased the activities of Glutathione peroxidase(GPX) and Catalase ( CAT), decreased the contractions of Lipid peroxidase (LPO) and Lactate(LD) in th e cerebral ischemia-reperfusion rats; shortened the longth of thrombus and impr oved the
blood rheology in the carrogeenin-induced thrombus model rats, and pro longed hypoxia-resisting time in mice. Conclusion: NST ca n evidently increase CBF in rabbits, improve the cerebral edema brain tissues'i njure and nervous physical sign indexes in the cerebral ischemia-reperfusion ra ts, reduce the infarct areas in MCAO rats, postpone thrombosis course and have a ntioxidation effects, which show that NST can obviously protect the brain tissue s in the experimental
cerebral infarct model rats.