Search
×

Sign up

Use your Facebook account for quick registration

OR

Create a Shvoong account from scratch

Already a Member? Sign In!
×

Sign In

Sign in using your Facebook account

OR

Not a Member? Sign up!
×

Sign up

Use your Facebook account for quick registration

OR

Sign In

Sign in using your Facebook account

Shvoong Home>Medicine & Health>Study on Association Between Interleukin-1 β Gene Polymorphism and Benazepril Response Review

Study on Association Between Interleukin-1 β Gene Polymorphism and Benazepril Response

Article Review   by:TsingHua     Original Author: Journal of University of Science and Technology of China
ª
 
To examine whether interleukin1β gene (511) polymorphism is associated with therapeutic effect of a kind of angiotensin 1 converting enzyme inhibitors (ACEIs), benazepril. Individuals with essential hypertension were recruited from Yuexi County (n=594) and Huoqiu County (n=352), in Anhui, China, and were treated with benazepril for 15 consecutive days. Patients' blood pressure was measured and blood sample from subjects were collected. The interleukin1β (511) genotype was determined using the polymerase chain reactionrestriction fragment length polymorphism (PCRRFLP) analysis. Linear and logistic regressive analyses were conducted to test for the association between interleukin1βgenotype and drug response. In linear regression the blood pressure drop was considered as the dependent variable. In logistic regression the drug response was considered as a dichotomized trait. Covariates were adjusted in the regression models. Both Linear and logistic regression analyses showed that there is no association between interleukin1β (511) polymorphism and blood pressure drop after 15 days of benazepril treatment in samples from both Huoqiu and Yuexi. Combination of data from both places yielded similar results, this suggests that interleukin1β genotype probably does not affect the therapeutic effect of benazepril.
Published: August 30, 2003   
Please Rate this Review : 1 2 3 4 5
Translate Send Link Print
X

.