Objective To explore the airway response to mixed gas of sulfur dioxide(SO2) and nitrogen dioxide (NO2) in guinea pigs
Methods 40 guinea pigs were divided into 4 groups averagely as following,A group
inhaled mixed gas of 14.3 mg/m3 SO2,3 1 mg/m3 NO2 and air,B group inhaled mixed gas of 28.6 mg/m3 SO2,6 1 mg/m3 NO2 and air,C group inhaled 42.9 mg/m3 SO2,10.3 mg/m3 NO2 and air,control group inhaled air The intratracheal pressures (IP) of airway of the observed guinea pigs were determined at the 0,5 th,10 th and 15 th minute after the
inhalation of mixed gas The experiment on the airway response to the observed mixed gas excited by inhalation of histamine aerosol was carried out also Results The levels of IP increased at the 5 th minute after the inhalation of 3 kinds of mixed gas of SO2 and NO2 in A,B and C groups,and declined at the 15 th minute after the inhalation of mixed gas in guinea pigs of A and B groups No significant differences were observed in the IP levels at different monitoring moments in every group(P￡3/40 05) The levels of PC20 induced by histamine aerosol in A,B and C groups revealed significant differences compared with those in control group(P<0 05) Conclusion The short term inhalation of mixed gas of SO2 and NO2 might result in the increases of the airway response in guinea pigs