Objective To study the effect of Rholida on free radical metabolism and serum creatine kinase(CK) after exercise at
plateau.
Method After staying at high altitude(4100 m) for 20 d , 40 healthy young men were divided into 4 groups randomly ( Rholida ,Acetazolamide, Xi ,s
capsule and control, 10 men each group).And their SOD,MDA,GSH Px CK, and CK MB were determined respectively.Before,after taking drugs and after finishing the 5 min stair exercise. Result Before taking drugs and after exercise,MAD GSH Px, CK, CK MB,
increased as compared with quiet state(P<0.05,P<0.01),but SOD showed no significant chang (P>0.05).After taking drugs for 6 d,those who took Rholida,Acetazolamide and Xi ,s capsule,their MAD,GSH Px CK, CK MB increased after exercise as compared with quiet state (P<0.05).In Rholida group SOD increased and had significant change(P<0.05);but there was no significant change in Acetazolamide,Xi ,s capsule group,SOD increased,MDA decreased(P<0.05),CK,CK MB had no significant change (P>0.05),GSH Px increased in Xi ,s group(P<0.05),but not in Acetazolamide group(P>0.05).SOD,GSH Px increased, MDA, CK MB decreased in Rholida group after taking drugs and the changes were significant(P<0.01).In Acetazolamide and Xi ,s capsule group,GSH Px increased significantly,MDA,CK,CK MB decreased significantly(P< 0. 05) , but SOD didn ,t(P>0.05). Conclusion Rholida, Acetazolamide, Xi ,s capsule could regulate the disorder of free radical metabolism at plateau and Rholida had advantage over the others.