OBJECTIVE:To study the effect of
Spirulina Compound Tablet(Fst) on the level of serum lipids in
hyperlipidemic mice.METHODS:The
experimental
hyperlipidemic mice were divided into four groups.Among them,two groups were treated with FST 1.5g/kg,3g/kg respectively by ig administration,and one group was given lipanthyl 0.05g/kg by ig administration as the positive drug control,another group was received physiological saline by ig administration as the hyperlipidemic control.The treatment were consecutively carried out for 14 days.Then the serum lipids of each group were determined with automatic biochemistry analysor.RESULTS:Compared with the hyperlipidemic control group,it was found that FST could significantly decrease the level of total serum cholesterol(TC),triglyceride(TG),and low density lipoprotein cholesterol(LDL C),as well as remarkably increase the content of serum high density lipoprotein cholesterol(HDL C) and the value of HDL C/TC in the hyperlipidemic mice.Furthermore,the results also showed that FST could obviously raise the concentration of the serum apolipoproteinAI(apoAI) and reduce the concentration of apolipoproteinB(apoB)(Whereas FST 1.5g/kg had no significant effect on apoB).CONCLUSION:FST could remarkably decrease the content of serum lipids and regulate the apolipoprotein in the hyperlipidemic mice.