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Shvoong Home>Medicine & Health>Experimental study on preventing obesity by compound rhubarb preparation in rats Review

Experimental study on preventing obesity by compound rhubarb preparation in rats

Article Review   by:TsingHua     Original Author: Chinese Journal of Pathophysiology
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AIM: To investigate the effect of compound rhubarb preparation (Kintop) in preventing obesity in rats and its probable mechanism involved. METHODS: Twenty-six newborn SD rats were randomly grouped as rhubarb preparation plus high-energy forage group( n= 8), high-energy forage control group( n= 8) and ordinary forage control group( n= 10). The rats in rhubarb preparation plus high-energy forage group and high-energy forage control group were fed with high-energy forage and those in ordinary forage control group were fed with ordinary forage. The rats in rhubarb preparation plus high-energy forage group were administered by compound rhubarb preparation (40 mg·100 g -1 body weight·d -1 ) from 9th to 17th week. The dynamic changes in body weight, celiac fat weight and adipocytes size were measured. Immunohistochemical analysis of leptin in celiac adipocytes (ABC method) and measurement of serum leptin level (RID method) were performed. RESULTS: The body weight and the wet weights of celiac fat were lower, their adipocytes were smaller and immunohistochemical stainings of leptin were weaker in rhubarb preparation plus high-energy forage group than those in high-energy forage control group. There was an obvious positive correlation between the expression of leptin and celiac fat tissue weight( r= 0.8663, P< 0.05). But the changes in serum leptin were not significant between groups. CONCLUSION: Compound rhubarb preparation (40 mg·100 g -1 body weight·d -1 ) can prevent the obesity in rats fed with high-energy forage. The mechanism might involve the decrease in adipocyte leptin expression. <
Published: July 30, 2001   
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