Objective To explore the virus
inhibitory effect of Chuan Kang Ping Granule. Methods\ Using tissue culture techniqe, the
maximal non toxic concentration of the drugs in Hep 2 cell culture were measured and the virus
inhibitory index of the drugs on the respiratory syncytial virus (RSV),the coxackie B 3 virus (Cox B 3)and the influenza A 1 virus (A 1) was calculated. In addition,the degrees of inhibition of the drugs on the cytopathic effect of
viruses in cell culture was observed by changing sequence of adding the viruses and the drugs. Results The maximal non toxic concentration of Chuan\|Kang\|Ping Granule was 1∶16. The virus inhibitory index on RSV,CoxB 3,A 1 was 8,8 and 2, respectively The maximal non toxic concentration of Shuang Huang Lian oral administration Liquid was 1∶32. The virus inhibitory index on RSV,CoxB 3,A 1 was 8,16 and 2, respectively, The degrees of cytopathic effect were different when changing sequence of adding the viruses and the drugs. Conclusion Chuan Kang Ping Granule inhibited the replication of RSV,CoxB 3,A 1 in cultured cells. The inhibitory effects of the drugs were the same or nearly the same with Shuang\|Huang\|Lian oral administration liquid. The mechanism of the inhibitory effects of the drugs on the viruses was probably the direct killing effect in vitro, or the drugs might inhibit some key link of the replication of the viruses in cultured cells.