Objective:To study the effects of shuxuening injection ( Ginkgo biloba extract for intravenous injection) on hemorheology
and
thrombokinesis in vivo of rats.Methods:The hemorheologic study was conducted in
rat's model with hyper viscosity(RMHV)and the experiment on thrombokinesis induced by electric stimulation was conducted in rats in vivo .Results:①?After subcutaneous injection of adrenaline,the viscosity of whole blood and plasma in RMHV were increased at different shears in comparison with nomal rats.②?After intravenous administration of 0.5ml/kg shuxuening injection,the decrease in whole blood viscosity in RMHV at different shears(1s -1 ,5s -1 ,50s -1 ,100s -1 ) were 24.3%,21.4%,19.9% and 16.5%( P <0.01 for all) respectively,the corresponding decrease in plasma viscosity were 17.4%,19.6%,18.2% and 16.6%( P <0.05 for all) respectively;and no effect on erythrocytic aggregation index was observed.③?After intravenous administration of 0.75ml/kg shuxuening injection,the decrease in whole blood viscocity in RMHV at different shears(1s -1 ,5s -1 ,50s -1 ,100s -1 ) were 61.6%,44.6%,24.6% and 26.0%( P <0.001 for all) respectively;the corresponding decrease in plasma viscosity were 42.1%,44.8%,43.5% and 43.8%( P <0.001 for all) respeetively,the decrease in hematocrit was 12.5%( P <0.01) and erythrocytic aggregation index decreased markedly( P <0.001).④?30 minutes after intravenous administration of 0.5 and 0.75ml/kg shuxuening injection,the increase in thrombokinesis time was 68.8%( P <0.05) and 113.8%( P < 0.01) respectively.Conclusion:Intravenous administration of shuxuening injection can decrease the blood viscosity and prolong the thrombokinesis time in rats. <