To study the
histological mechanism of the lost bone of male rats eunuch prevented and treated by Chinese herb tonifying
kidney.Methods:Selecting ten month old male rats as pathological model.Whose testicles have been cut away,then dividing them into three groups as the following:normal group,pathological group,
Chinese herb tonifying kidney group.After feeding them drugs for 12 weeks.We kill them and choose L1 and L2 to make bone slices without decalcification,meanwhile,determinate diverse bone indexes and superficial indexes of bone morphological metrology and make ANOVA.Results:①All bone indexes in the pathological group are smaller than that in normal one( P <0 05).All superficial index prove:osteoclast index decrease;osteoblast index increase,bone transformation become faster than before.②All bone indexes of Chinese herb tonifying kidney group are higher than that of pathological group ( P <0 05).The superficial indexes are reversed,some osteoblastic cells are particularly active,under which bonemoid substance stands out from the peripheral static superface.Conclusions:Chinese herb tonifying kidney has three aspects of
histological mechanism to prevent and treat senile osteoporosis:①double effects of restraining bone absorption and promoteing bone formation,②reduce bone transformation,improve bone quality,③the short circuit effect during bone reconstruction.