Objective To investigate the effect of Yiqiwenyanghuwei decoction on plasma soluble intercellular adhesion molecule 1sICAM－1
levels in asthmatic guinea－pigs． Methods The guinea－pigs were at random divided into normal control group asthma group dexmethaone group Yupingfeng powder group and three
different dose＇s groups of Yiqiwenyanghuwei decoction respectively． The guinea－pigs＇ plasma samples were collected 24h after asthma provocated． The levels of plasma sICAM－1 were measured by enzyme linked immunosorbent assayELISA． Results The level of plasma sICAM－1 in asthma group was 141．94±78．24ng／ml there was a marked difference compared with those in the others＇ groupP＜0．05 The levels in normal control group was lowest in the seven groups namely 24．68±13．87ng／mlP＜0．05 The levels in Yupingfeng powder group 78．37±21．07ng／ml was
significantly different compared with those in the others＇ groupsP＜0．05 The level of plasma sICAM－1 in low－dose group and middle－dose group were significantly higher than those in dexmethaone group and high－dose groupP＜0．05 the levels of the former were 72．44±15．46ng／ml and 62．89±17．18ng／ml respectively there was not significant diference between the two groupsP＞0．05 the levels of the latter were 55．08±18．22ng／ml and 48．62±18．32ng／ml there was not significant difference between the latter groupsP＞0．05． Conclusion Yiqiwenyanghuwei decoction can lower plasma sICAM－1 levels in the asthmatic guinea－pigs．