Objective To observe the expression of β APP and SS in the
hippocampus of the rat mode ls with the deficits of learning
and memory function, and investigate its mechanism.Methods Using immunohistochemistry (IHC), we detected the expressions of β amyloid precursorprotein(β APP) and somatostatin(SS) in the
hippocampus of the rat brains,using HE staining method, we observed the shapes and structures of pyramidal cell layer neurons in hippocampus of the rats in the
experimental group and the controls.Results The learning and memory functions were lower significantly in the experimental group than in the controls ( P <0.01);The expression of β APP in hippocampus of experimental group was significantly higher than the controls ( P <0.01);but the number of SS immunoreactive positive neurons decreased sigificantly ( P <0.01); There was negative relation between the positive degrees of β APP and SS in the experimental group ( P <0.05).The structures of neurons in hippocampus of the experimental group and the controls were fundamental normal,there was no significant difference between the numbers of their neurons.Conclusion The pathogenesis of aluminum slat resulted in the deficits of learning and memory functions in rats,it might be related to the changes of the expressions of β APP and SS in brain.