AIM: To investigate the clinical features and nosogenesis of
drug induced liver disease (DILD). METHODS: The retrospectively
study on the clinical data of 103 cases of DILD was taken. RE- SULTS: The DILD account for 9.6% of in-patients with "acute hepatitis" in the corresponding period. There were many medicines that could produced liver lesion, but antituberculous were the most (account for 45%), and followed by
Chinese herbal medicines (20%); it was the commonest that produced liver lesion in the 2nd-4th wk after took medicine (66%), and in the 2nd wk next (26.2% ); acute hepatocellu- lar hepatitis was the commonest on clinic (62.1%), and 5 cases occurred fulminating hepatic failure (4.9%) among them; the fatigue, anorexia, nausea, vomiting and abdominal distension were principal clinical manifestation (71.8% ), and followed by the jaundice (59.2% ) ; ALT, GGT and BIL were higher after liver function lesion; there were 65 cases for clinical cure (63.1%), 34 cascs for improvement (33%), and 3 cases for death (2.9% ). CONCLUSION: The clinical manifestation of DILD has not speci- ficity, and is similar to virus hepatitis. The drugs that caused liver lesion include those medicines for every clinical department. The incidence rate of liver lesion caused by Chinese herbal medicines that were thought safety in the past has been increasing gradually (account to 20% ), and must be pay attention to.