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Shvoong Home>Medicine & Health>Experimental study on antiatherosclerotic effects of amlodipine in rabbits Review

Experimental study on antiatherosclerotic effects of amlodipine in rabbits

Article Review   by:TsingHua     Original Author: Editorial Departmert of Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Disease
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Objectives To observe the antiatherosclerotic effects of amlodipine and to investigate its mechanism.Methods 32 male rabbits were randomly divided into four groups:control group(fed with stock diet),model group(fed with high cholesterol diet),nifedipine treatment group (fed with high cholesterol diet plus nifedipine) and amlodipine treatment group (fed with high cholesterol diet plus amlodipine).All rabbits were fed for 60 consecutive days.Levels of plasma and erythrocytic indices including lipid,lipid peroxides,erythrocytic membrane fluidity(M Flu),plasma endothelin (ET),blood platelet activating factor(PAF),and platelet aggregation rate(PAR) were measured before and on 30th,60th experimental days,and all of the rabbits were sacrificed for histochemical and pathological studies of the heart,aorta and liver after the experiment.Results Like nifidipine,amlidopine could effectively lower levels of blood ET,PAF and elevate HDL C level,decrease deposition of cholesterol in aorta,liver and erythrocytic membrane,prevent lipid peroxide injury in blood and tissues,maintain functions of vascular endothelium and erythrocyte,modulate vascular smooth muscle cell phenotypes and control their proliferation,lower platelet aggregation activity.Conclusion Amlodipine has obvious antiatherosclerotic effects in rabbits.
Published: February 15, 2001   
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