Objective To observe effects and mechanism of ligustrazine in treatment of
retinal vein obstruction.Methods 35 patients
with
retinal vein obstruction were treated with ligustrazine.As control group,30 patients were treated with xuexhuantong.The curative effect was evaluated according to fluorescin fundus angiography findings,improvement of visual functions and fundus examination.Results By four course of treatment,82.9% were effective in the patients treated with ligustrazine and conformed with
xueshuantong.But in the recovery of vision,the treatment group was better than that of the control group.Conclusions Ligustrazine have better effects in treatment of retinal vein obstruction. Key Words Retinal vein obstruction; Ligustrazine; Xueshuantong纾? ｐｏｒｔａｌ ｖｅｉｎ．Ｇａｄｏｌｉｎｉｕｍ ｃｈ loride(GdCl 3,7mg/kg body weight),known for its ability to inhibit Kupffer cell phagocytosis,was given by portal vein to prevent the induced tolerance.Seven day s after the induction,BALB/C rats were i noculated on the dorsal flanks with eryt hrocytes free spleen cells(10 7/L).Mixed lymphocyte reaction(MLR)of BALB/C rats to NIH/q mice alloantigens was investiga t ed,and delayed-type hypersensitivity(DTH )response to NIH/q mice alloantigens wa s assessed by direct challenging BALB/C rats footpad 7 days later with NIH/q spl een cells(10 7/L)free of erythrocytes. RESULTS Both systemic venously inje cted neuraminidase-treated allogenic spl een cells,and portal venously injected u ntreated allogenic spleen cells,signific antly abolished BALB/C rats′ capacity to develope MLR and DTH response to NIH/q mice′s alloantigen.With simutaneouly in jected GdCl 3 which inhibited Kupffer ce ll′s phagocytosis,neither systemic venou sly injected neuraminidase-treated allog enic spleen cells,nor portal venously in jected untreated allogenic spleen cells, significantly abolished BALB/C rats′ cap acity to develope MLR and DTH response to NIH/q mice′s alloantigen. CONCLUSION Selective alloan tigen uptake by Kupffer cell s in the liver of BALB/C rats is essenti al for the induction or prevention of po rtal venous tolerance to NIH/q rat′s spl een cells.