Objective: To evaluate and compare the protective effect of talcid against NSAIDs induced gastric mucosal damage with other
gastroprotective drugs such as tagamet and sucralfate. Methods: NSAIDs induced gastric mucosal damage model in rats was obtained by
indomethacin. In other group,
pretreatment with talcid, tagamet or sucralfate was performed 1 hour before indomethacin intubation feeding. Morphological changes of gastric mucosa were assessed by light and scanning electronic microscopy in each group. Gastric mucosa blood flow (GMBF), 6 keto PGF 1α and TXB 2 level were also measured. Results: Indomethacin caused evident gastric damage. The epithelium was in poor arrangement and more cells were destroyed severely, bleeding was common, furthermore, some of which with exposure of lamina propriar. A marked reduction of GMBF, a powerful inhibition on 6 keto PGF 1α and TXB 2 level were detected at the same time (81.2% and 83.4% respectively, P <0.01 vs control). Pretreatment with the 3 drugs could reduce NSAIDs gastric mucosa damage to certain extent. Talcid increased GMBF significantly vs indomethacin, and the lesion index was 1.04±0.35 ( P <0.01 vs indomethacin). 6 keto PGF 1α and TXB 2 level were obviously increased at the same time. Sucralfate provided the best efficacy among them. Conclusion: Pretreatment with talcid has gastroprotective effect against NSAIDs mucosal damage to a certain extent.