AIM To observe the insulin sensitizing effect and
insulin resistance ameliorating effect of rosiglitazone. METHODS On the
IDDM model prepared by the intravenous injection of streptozotocin (50 mg·kg -1 ), the decrease of blood glucose of only rosiglitazone, only a low dose of insulin (2 5 U·rat -1 , sc), rosiglitazone plus a low dose of insulin on the models were calculated; On the immune model of
insulin resistance prepared by the intravenous injection of
bacillus calmette guerin (BCG, 10 mg·kg -1 ), the increase of glucose infusion rate (GIR) of rosiglitazone on the model was measured. RESULTS At three doses of 1、3、10 μmol·kg -1 ( po on successive 8 days), rosiglitazone decreased the blood glucose values neither of the normal rats nor of the diabetes rats induced by streptozotocin. However, rosiglitazone, at the doses of 3、10 μmol·kg -1 ( po on successive 8 days) plus a dose of insulin (2 5 U·rat -1 ·d -1 , sc on successive 8 days), decreased the blood glucose values of the diabetes rats induced by streptozotocin. Rosiglitazone, at a dose of 10 μmol·kg -1 ( po on successive 8 days) increased the GIR (glucose infusion rate) of the model, determined by both submaximal hyperinsulinemic euglycemic clamp and maximal hyperinsulinemic euglycemic clamp. CONCLUSIONS Rosiglitazone possesses the insulin sensitizing effect and insulin resistance amelioration effect.