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Shvoong Home>Medicine & Health>STUDY OF EFFECT OF INHALED HEPARIN ON BRONCHUS IN GUINEA PIGS Review

STUDY OF EFFECT OF INHALED HEPARIN ON BRONCHUS IN GUINEA PIGS

Article Review   by:TsingHua     Original Author: Journal of Guangxi Medical University
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To study the effect of inhaled heparin on bronchus in guinea pigsMethods:①Thirty healthy guinea pigs were divided to 3 groups The animals of the three groups inhaled heparin,salbutamol,and natural so lution on ultrasonic device,respectivelyEach time of study was 20 minu tes,for seven daysThe animals of the three groups inhaled histamine phosphate in day 7The asthmatic latent period of these animals were recorded②Bronchus and lungs of the guinea pigs were perfused by natural solution,heparin,isoprote renol and histamine phosphate,respectively,for ten minutes in constant pressure Then the rate of flow of bronchus and lungs was determined (total six samples) Results:①The asthmatic latent period of the animals of the heparin group and salbutamol group were 126.6±43.51 second and 165.8±29.97 second,wh ich were longer than that in the natural solution group(P<0.05)②The r ate of flow of bronchus and lungs in guinea pigs was increased by isoproterenol and wa s decreased by histamine,which did not effected on heparin Conclusion:Inhale heparin can prolong asthmatic latent period of guinea pigs induced by histamine,its effects that dilate to bronchus is sim ilar with salbutamolBut heparin has no direct effect on bronchus smooth muscle The results show that heparin may be an effective bronchodilator,and may be us eful for treatment of asthma
Published: December 30, 2000   
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