Study on Pharmacokinetics of Qianlie Anshuan in Rats

Article Abstract by: TsingHua

Original Author: ACTO ANDROLOGICA SINICA

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This abstract was translated from 前列安栓在大鼠体内的药代动力学研究

WT5”HX>Objectives:To study absorption and distribution of Qianlie Anshuan in rats, probe into the method

in studying pharmacokinetics of compound recipes of Chinese materia medica, and provide an experiment evidence for the rational uses of Qianlie Anshan in clinic. Methods: After Qianlie Anshuan was administered to male rats via rectum at crude drug 5g(200 μ Ci)/kg, the radioactivity in blood, prostate, rectum and related organs was detected at prescript time. Results:Radioactivity was found in blood at 5 minute after administration. The blood concentration time curve was shown to fit a two compartment open model. Radioactivity was also found in target organ (prostate) at 5 minute after administration. Radioactivity was found to be higher in prostate than in any other organs except rectum, liver and kidney. Radioactivity in prostate remains a certain level at 24h after administration. Next to rectum, the radioactivity in liver and kidney was the highest. Conclusions: After administration via rectum, Qianlie Anshuan was absorbed rapidly, and distributed rapidly to target organ(prostate). Higher concentration of the drug in prostate is especially helpful for therapies of prostatitis and hyperplasia of prostate. Liver and kidney seemed to be the main routes of metabolism and excretion of the drug.

Published: June 30, 2000

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