To study t he pharmac ology of frozen and natural dried Lycium barbarum. Methods The effect of anti-fat
igue,white blood cells count(WBC),and ph agocytosis were tested in the mice by me ans of feeding with frozen and natural d ried Lycium Barbarum. Results An obviousl y increased time of swimming were found in the mice fed with 65g/kg of frozen an d natural dried Lycium Barbarum,there wa s an significantly difference between th e experiment and the control group (P< 0.0 1).The swimming time in the mice fed wit h frozen dried Lycium Barbarum was signi ficantly longer than that in the natural dried Lycium Barbarum (P<0.01).WBC in the mice fed with 10g/kg Lycium Barbaru m dried frozenly and naturally was signi fic antly more than that in the control grou p (p<0.01).The phagocytosis rate of ph ag ocytes in the abdominal cavity in the m ice fed with frozen and natural dried Ly cium Barbarum(50g/kg) was significantly higher than that in the control (P<0.0 1) .No significant difference of WBC and ph agocytosis rate were found between the m ice fed with frozen and natural dried Ly cium Barbarum. Conclusions The ef fect of anti-fatigue of frozen dried Lycium Barb arum was stronger than that of natural d ried one