Objective: To study whether sodium
thiosulfate (STS) can be used as an
adjuvant of the
chemotherapy drugs. Methods:
The
cytotoxicity of STS combined with ADM, MMC, CDDP, 5Fu, MTX and VCR (1PPC/ml) respectively
on the cells of BEL7402 and MGc803 was studied by MTT test in vitro. The ascitic hepatoma
(H22) in mice were adopted to determine the anticancer effect of STS
adjuvant of ADMMMC and
CDDP. Being treated with STS(12525 g/m2) 30 min before drug administration,20 patients of
hepatocellular carcinoma (HCC) were carried on transcatheter arterial chemoembolization with
ADMMMC and CDDP to observe the adjuvant effect of STS. Results: The anticancer activity of
ADM and the other agents respectively adjuvant with STS (500 g/ml) were not obviously
influented (P >005), but that for CDDP was influented . It was proven that the survival time of
ascitic hepatoma treated with ADM (6 mg/kg),MMC (14 mg/kg) and CDDP (45 mg/kg) alone or
three drugs in addition to STS (350 mg/kg,35 mg/kg) respectively was not significantly different
(P >005). The survival time of each groups was significantly longer than that of control group
(P< 0001). It have also been proven that STS adjuvant of ADM, MMC and CDDP was not
decreased the chemotherapry effect (RR=60%) by transcatheter arterial chemoembolization in
HCC, simultaneously it alleviated the nausea and vomiting in 70%patients. Conclusion: The
study provides evidence that in vivo, STS (12525 g/m2) can be used as an adjuvant of
chemotherapy drugs,such as ADM,MMC, including CDDP, and so on , for decreasing nausea
and vomiting effects, espacially for transcatheter chemotherapy .