Plasma concentration was determined with opposite direction liquid chromatography on six healthy rabbitand six
artificialinfect
pasteuriaceae rabbitafterintramuscularinjected .The re sult showed that experimentalresult bedecriptive well with one compartment model with control of unlinear lowest dual multiplication .After intramuscular injected ,there is a short slow moving period ,(lagtime of healthy rabbit= 3-4664 ±1-1490 min ,lagtime of
artificialinfect pasteuriaceae rabbit = 4-1984 ±0-9615 min) .Then plasma concenration increased rapidly and distrilbution phase finished soon ,t1/2ka of healthy rabbit = 6-6432 ±3-6677 min ,t1/2ka of artificialinfect pas teuriaceae rabbit= 5-4884 ±1-9337 min .tp of healthy rabbit= 39-1972 ±11-8951 min ,tp ofarti ficialinfect pasteuriaceae rabbit = 27-4670 ±6-0121 min .Finally ,there is long clearance phase , t1/2kelof healthy rabbit = 242 .7080 ±52-2765 min ,t1/2 kelof artificialinfect pasteuriaceae rabbit= 160-8238 ±66-1273 min ,Vd(apparent volume of distribution) of healthy rabbit = 2-6470 ± 1-5418 L/kg ,Vd of artificial infect pasieuriaceae rabbit = 1-5229 ±0-4280 L/kg .CLB(bodyclearance)of healthy rabbit = 7-1000 ±2-6000 m L/(kg·min) ,CLBofartificalinfect pasteuriaceae rabbit= 8-0167 ±4-9603 m L/(kg·min) .There is no significant difference the plasma concentra tion of healthy rabbit and that of artificialinfect pasteuriaceae rabbit( P> 0-05) ;there is signifi cant difference between t1/2kel of healthy rabbit and that of artificial infect pasteuriaceae rabbit ( P< 0-05) and there is no difference between the other pharmacokinetic parameter of healthy rabbit and that of artificialinfect pasteuriaceae rabbit( P> 0 .05) .