Objective:To investigate the effects of angiotensin converting enzyme inhibitor
benazepril on
insulin resistance hypertensive
rat model
.Method:Male Sprapue Darley rats fed on high sucrose and high salt diet (35% suscrose 4% salt by weight, SSFR) or standard chow for 4 weeks and treated with either benazepril (3 mg·kg -1 ·d -1 ,n=9; 10 mg·kg -1 ·d -1 ,n=9) or vehicle (n=10) for the later 4 weeks. Another SSFR group (n=9) preventively treated with benazepril for 4 weeks. Steady state plasma glucose (SSPG) was measured, simultaneosly infusing insulin ( 2.5 mu·kg -1 ·min -1 ) and glucose (8 mg·kg -1 ·min -1 ) to determine insulin sensitivity of each group.Systolic blood pressure (SBP),serum trigliceride, glucose and insulin level were meassured. Result:SBP was higher in SSFR compared to control ( 148.4 ± 18.8 mmHg vs 125.5 ± 13.2 mmHg,P< 0.05 ),SSPG was also higher and decreased from control 11.20 ± 2.32 mmol/L to 8.49 ± 2.85 mmol/L(P< 0.05 ) in the 3 mg·kg -1 ·d -1 treated group and to 7.45 ± 1.50 mmol/L (P< 0.01 ) in the 10 mg·kg -1 ·d -1 treated group after 4 weeks treatment , in the preventive group, SSPG was not higher than the control. Conclusion:High sucrose high salt induces ISR.Benazepril treatment improves ISR or may prevent ISR in the SSFR.