Objective The effects of delayed
hypothermia combined with batroxobin on behavior and histopathology following
global cerebral ischemia in gerbils were studied.Methods The ischemia was induced by occlusing the bilateral common carotoid arteries for ten minutes.Thirty five gerbils were divided into five groups:sham operated group;
normothermia group;delayed
hypothermia group;batroxobin group;delayed hypothermia combined with batroxobin group.Open field test were carried out at the fifth day,and histopathology test at the seventh day.Results The exploring activities of gerbils in both batroxobin and delayed hypothermia group were lower than that in normothermia reperfusion group,but higher than in hypothermia combined with batroxobin group.Animals of batroxobin group or delayed hypothermia group showed less neuron loss of CA1 than that of normothermia group,but more neuron loss of CA1 than that of hypothermia combined with batroxobin group.Conclusion Batroxobin or delayed hypothermia provides neuroprotective effects from the behavior deficits as well as neuronal injury following transient global cerebral ischemia,and their efficacy is substantially elevated when the treatments are combined.