Objective To observe the hemodynamic and concentration of plasma catecholamines changes during laparoscopic cholecystectomy (LC) under general anesthesia or combined with epidural anesthesia Methods Twenty patients,scheduled for LC,were randomly divided into general anesthesia group (A group,n=11) and general anesthesia combined with epidural anesthesia group (B group,n=9) The hemodynamic changes after peritoneal insufflation of CO 2 were measured with Swan Ganz catheterization,and the plasma concentration of epinepherine (E) and nonepinepherine (NE) were measured before and after CO 2 being insufflated into peritoneal cavity with high performance liquid chromatography electrochemical method Results (1) Both concentraitons of NE and E were increased significantly after peritoneal insufflation in A group (P<0 05),while no obvious changes in B group (P>0 05) (2)HR,MAP,CVP,SVR and CI were increased significantly while SV had no obvious change after peritoneal insufflation in A group; in B group, all parameters had no significant changes except CVP was significantly increased Conclusion The combination of general and epidural anesthesia can suppress the stress response and stablize the hemodynamics during LC