Objective To explore the effect of Radix Salivae Miltiorrhizae on blood air and pulmonary weight index of rats suffuring from ARDS disease,and its regulating role on tumor nectosis factor(TNF a)and interleukins-l(IL-1) secretion in ARDS rats'alveole macrophages.Methods We make ARDS rats model by intraventing oil acid as the oil acid group.We take groups intravented with physiological saline as the control,and groups intravented with oil acid and simultaneously perfusated with Radix Salivae Miltiorrhizae into the stomach as treatment group.After intraventing oil acid and physiological saline for six hours.We measure the PaO 2 and PaCO 2 of the left heart and the pulmonary weight index.Then we separate and culture the alveolar macrophages of each group,and measure the quantities of TNF a and IL-1 by MTT method.Results The PaO 2 value of the oil acid group is more than the other two groups( P< 0 001).The bloods air of the treatment groups is better than the oil acid group( P< 0 05).The pulmonary weight indes of the three groups are oil acid group(1.03±0 06),the treatment group(0.72±0.05),the control group (0.
64±0.06).There are significant differences among these groups( P< 0 01).The quantities of TNF a and IL-1 respectively are:the oil acid group(72.06±5 64)%、(96.22±11.61)U/ml,the control group(7.75±1.05)%、(21.05±3.11)U/ml,the treatment group(35.44±4.55)%、(70.66±8.23)U/ml.The secretion quantities of TNF a and IL-1 in oil acid group is far more than that in control group( P< 0 001).The treatment group also has higher level secretion than the control group,but its level lower than the oil acid group( P< 0 001).Conclusions Radix Salivae Miltiorrhizae can treat and protect ARDS rats with lung injury.It can also inhabit the excessive activation of alveloar macrophage in ARDS rats and reduce the secretion of TNF a and IL-1.The researches on the regulation of cellular factors secretion in alveolar macrophages are significant to recognize the pathogenesis of ARDS and guide clinical treatment. <