Objective: To investigate the effect of Qngdutuire decoction powder(QDP) on endotoxie fever and itsinflueneon plasma arginine pitressin (AVP), endotoxin (ET ) and nitric oxidc (N0 ) levels. Meth0ds: 165 pationtswith endotoxic fever were randomly divided int0 2 groups: cither trcatment with QDP group(n = 12O) or antibioticgroup(n = 45), and 30 healthy volunteers served as controls. Changcs in plasma AVP, ET and NO lcvcls werc de-termined in patients before and after treatment. Results: There were significant differcnce betwecn thc QDP groupand the antibiotic group in cure rate and mean course of therapy(P < 0. O5 ). After QDP trcatmcnt, plasma AVP,ET and NO levels wcre(7. 09 ±O. 52pg/mL, 0. 12 t±0. 08EU/mL and 89. 03±14. 74μmol/L) respectively, whichwere significantly low comparcd with that prior to therapy(10. 46 ±0. 80pg/mL, 0. 47 ±0. 6EU/mL and 124. 6l ±l7. l9μmol/L boh P < 0. 01 ). After antibiotic treatment, plasma ET levels(0. 28 ± 0 . 05EU/ml,) wcrc significant-ly high compored tith that QDP group(0. l2 ± 0. 05EU/mL both P < 0. 01 ). Conclusions: QDP has a good effect onpatients with endotoxic fever. It also has regulatory effect on AVP, NO and ET. QDP is of bcnefit in reducing in-flammation , kill germ, allay a fever and eliminate end endotoxin in patients with endotoxie fever.