lnordertoinvestigatethecompatibilityfunctionandsignificanceoftheantipathogenicabilitysupplementing andstagnation dispersingpurposeintheantipathogenicability
supplementingandstagnation dispersingformulaforresist inghepaticfibrosis ,theantipathogenicability
supplementingandstagnation dispersingformulawasdividedintothean tipathogenicability supplementinggroup(cordycepshyphae ,pinepollen)andthestagnation dispersinggroup(RadixSalvi aeMiltiorrhizae ,SemenPersicae) .Aftertheratswerefedwithdrugs ,thedrugserumwasseparatedtoobserveinfluenceof drugseruminvariousgroupsonexpressionofratstellatecell (HSC)astrocyteα smoothmuscleactin(SMactin ,α SMA) byregenerationandactivationinvitro ,onincorporationof <3H>TdRand <3H>Pro ,onexpressionofmodellprocollagen mRNA ,ontheformationvolumeofcollagenandalbuminofrathepaticcells .Theresultsshowedthattheexpressionof HSCα SMAandincorporationvolumeofintracellular3H TdRinvariousgroupswereremarkablylowerthanthecontrol group ,remarkablylowerinthestagnation dispersinggroupthanintheantipathogenicability supplementinggroupandthe wholeformulagroup .TheexpressionofmodellprocollagenmRNAandformationvolumeofcollageninHSCinvarious groupswereobviouslydecreasedandtheantipathogenicability supplementinggroupwasalsoremarkablylowerthestagna tion dispersinggroupandthewholeformulagroup .ThewholeformulacangreatlyenhancetheAlbformationvolumeofthe hepaticcells ,buttherewasnoobviousinfluenceintheantipathogenicability supplementinggroupandthestagnation dis persinggroup .Theconclusionisthatthefunctionofthestagnation dispersingdrugstoinhibitHSCactivationispredomi nantandthefunctionsoftheantipathogenicability supplementingdrugstoinhibittheexpressionandformationvolumeof modellprocollagenmRNAarepredominantintheantipathogenicability supplementingandstagnation dispersingformu la .Thewholeformulanotonlymaintainstheabove mentionedantipathogenicability supplementingandstagnation dis persingfunctions ,presentsitseffectinpromotingsynthesisofcellularprotein ,theformationvolumeofalbuminofthehep aticcellsinparticularandalsoshowsthecomprehensiveadvantageoftheantipathogenicability supplementingandstag nation dispersingfunctioninresistinghepaticfibrosis .