Aim The effects of
Naoluotong, a cempeund of Chinese medicine on
atherosclerosis were studied.Methods One hundred and twenty
male quails were divided at random into 6 groups.The quaits in 5 groups ,including the control group,
Naoluotong (3,6,12 g·kg-1·d-1) groups, and Yuejiancao oil (6 g·kg-1·d-1) group,received hyper-fat forage, and in the sixth group were fed on stock diet.Half of the quails in each group were kill 4 wk after.The levels of TC,TG,LDL-C,VLDL-C and HDL-C in serum were measured in biochemilal method.The remainder quails were fed on above forege continuously for another 4 wk and then were killed.The levels of TC,TG,LDL-C,VLDL-C and HDL-C in serum and the contents of TC and TG in myocardium and aorta were tested,and the change of endo-aorta was determined. Results The levels of TC,TG,LDL-C and VLDL-C were decreased,the level of HDL-C and the vatio of HLD-C/TC were increased by Naoluotong (6,12 g·kg-1·d-1) in the quails fed on hyper-fat forage for 4wk (P<0.05,P<0.01).In the remainder quails which were raised for 8wk,the above items were similar to the quails fed for 4wk,the effelts of Naoluotong was dose-dependent in adjusting blood lipid,and the contents of TC and TG in aorta and myocardium were decreased (P<0.05)and the lesion of endo-aorta was also improved by Naoluotong (6,12 g·kg-1·d-1). Conclusion Naoluotong has the action to adjust blood lipid-adjusting and to antagouise
atherosclerosis.