Aim: The serotypes of the
Pseudomonas aeruginosa (P. aeruginosa) in respiratory
tract infection specimensand antibacterial activity in vitro of 12 antibiotics werestudied. Methods: After the specimens were purely cultured, VITEK-AMS Microbe Auto-analysis Instrument wasused for the identification of bacterial PA20 series serumwas used for the serotypes; K-B paper strip method in accordance with the NCCLS standards was employed for sensitivity tests. Results:The
serotype rate of the 58
strains ofP. aeruginosa which caused respiratory tract infection was94. 83%, with the predominance of PA6,PA2,PA4 types.The average drug-resistance rate of the 58 strains bacteriato the 12 antibiotics was 47.6 %. The drug-resistance ratesto
Sulperazone, Ofloxacin and Imipenem were all less than12. 1 %;to Piperacillin, Cefotaxime, Timentin, all morethan 62. 4%. Five more drug-resistance
bacteria accountedfor 70.7%. Among the 58 strains bacteria, β-lactamase-producing strains accounted for 63. 8%. The drug-resistancerates of the zymogenic bacteria to Sulperazone, Ofloxacin,lmipenem were all less than 18. 9%, while to Rocephin,Piperacillin, Cefotaxime,Timentin,more than 68. 4%. Fivemore drug-resistance bacteria accounted for 83. 8%. Conclusion: In the treatment of respiratory tract infection causedby P.
Aeruginosa, before the result of bacteria drug-sensitivity,Sulperazone or Ofloxacin containing enzyme inhibitorwith Gentamicin or Amikacin are the best choices. In thecase of zymogenic bacteria, Sulperazone, Ofloxacin orImipenem are the best choices. In the case of non-zymogenicbacteria, general antibiotics such as Cefoperazone or Ceftazidime, together with Gentamicin, Tobramycin orAmikacin etc. can be used.
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