OBJECTIVE: To investigate the effects of low molecular weight
heparin (LMWH) and heparin
injected intravenously and subcutaneously respectively on
thrombosis and blood coagulation. METHODS: Two thrombus models were established according to Chandler's method and to Reyer's method. Clotting time (CT), prathrombin time (PT), thrombin time (TT), active partial thromboplastin time (APTT), and recalcification time (RT) were measured. RESULTS: When injected intravenously, the weight of thrombus in
LMWH group was lighter than that of heparin at the same anticoagulant unit in Chandler's thrombosis model and similar to that of heparin in Reyers' model. LMWH could prolong the CT, PT, RT, APTT to the same extent as heparin, with the exception of TT which was shorter in LMWH group. When injected subcutaneously, the weight of thrombus in LMWH group was lighter than that of heparin both in Chandler's model and in Reyers' model. Furthermore, the CT, PT, APPT, TT and
rt in LMWH group were longer than those of heparin. CONCLUSION: LMWH iv showed antithrombotic effect is more potent than heparin or at least similar to heparin, with the effect on blood coagulation weaker than heparin. When injected subscutaneously, the antithrombotic effects and anticoagulant effects of LMWH were more potent than those of heparin.
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