Objective: To study the therapeutic mechanism of Yangxue Bushen tablet (tablet for nourishing blood and tonifying Kidney)
on the Kidney deficiency type of functional amenorrhea and
infrequent menstruation. Methods: Applied with orimeten, models of Yang deficiency in female rabbits were made, ikaclomine was taken as the control drug. Group Ⅰ was the group of
animal model of Yang deficiency; Group Ⅱ was the ikaclomine treatment group; Group Ⅲ was the high dosage treatment group; Group Ⅳ was the low dosage group; Group Ⅴ normal rabbit treated with distilled water. The functional effect of gonadal axis was evaluated by the changes of the signs of animal histomorphology of ovary and uterus, and the level of β endorphin. Results: The animals of Yang deficiency in Group Ⅱ, Ⅲ and Ⅳ recovered as a whole, and the changes of different levels of folliculi, morphosis of endometria and deciduous vaginal epithelial cell in group Ⅱ, Ⅲ and Ⅳ were more obviously than those in group Ⅰ and Ⅴ (P<0 05). The content of β endorphin in blood plasma in group Ⅰ was 106.6pg/ml, which was lower than those in the other groups (P<0 05), and the contents of β endorphin in blood plasma, in group Ⅲ,Ⅳ and Ⅱ were similar to that in group Ⅴ (P<0 05). Conclusion: Yangxue Bushen tablet has the effect on regulating menstruation by regulating the function of gonadal axis, regulating and promoting the ovarian function.