Objective:Under the guidence of the theories of talihonal Chinese medicine and the classical recipe "Yan Shou Dan", to develop
anti-
senility medicines and health-care foods. Methods:The
modified preparetion Huichun Oral Liguid Was compared with the
original Yan Shou Dan by pharmacological methods and chinical trial use, and the physical and chendcal natures of all the pnducts were fully analysed. Results: Huichun Oral Liquid has remarkable
effects of anti-fatigue, anoxia endurance, supressing the of remahon of perokidaed lipid, reducing lipofuscin and scavenging free radical;it can also, take away the symptoms of "insamciencies of yang and the spleen"from animal models and reduce the death rate of the mice in cold tolermce test; it prolongs the life of fruit flies by 32.0% ~ 55. 8%. The original preparetion of yan Shou Dan,"Essence of Longevity",has similar effects,but with less indexes than Huichun Oral Liquid.The test also showed that the pharmaceutical ingredients in the four health-care bos had effects of anti-senility to different degrees. A clinical comparative study of 175 cases with coroneq heart disese showed that those trcaed with Huichtin Oral Liquid have boroved fority and greatly abated symptoms such as dizziness, tinnitus ,palpitation and short breath,the effectual rate being 57.0%, and the total effective rate,92.7%, much higher than the control group treated with "Essence of Iongevity" (P<0.01). Conclusion: The original preparehon of Yan Shou Dan and its modified preparation both have effects of building up the health, improving the intelligence and making senility go slowly, but the modified preparation has better effects than the original.