The effect of Shenkangning on experimental chronic renal disease in rats

? Shenkangning(SKN) is a compound preparation by composed of Chinese medicines.SKN showed a significantly effects on chronic nephropathy of patients in clinical treatment.The aim of this study is to investigate the effect of SKN on experimental chronic nephropathy.Nonimmunologic damage of chronic nephropathy in rats was induced a single iv administration of ADR(7.5mg/kg body wt) and immunologic damage of chronic nephropathy in rats was induced by repeated sc administration on renal medulla and Freund's complete sdjuvant.The results indicated that proteinuria,urinary creatinine,serum urinary nitrogen and serum urinary creatinine increased singificantly after iv ADR from d10 to d24 and repeated sc administration of renal medulla and Freund's complete sdjuvant from d30.Renal histological examination suggested a tubulointerstitial cellular infiltrate and glomerrular lesions were found in 0.9%NaCl group rats. The proteinuria, urinary creatinine,serum urinary nitrogen and serum urinary creatinine deceased in ADR rats treated by SKN(compare with 0.5% NaCl group rats,P<0.05 or 0.01) and the tubulointerstitial cellular infiltrate and glomerrular lesions were less than 0.9%NaCl group rats. The results suggested SKN was antiproteinuria and protected kidney in exprimental ADR and immunologic nephropathy.