The
antitumor effect of organic Germanium(Ge 132) and its enhancing effects on SOD activity and the anti hepatocarcinoma
effect of CTX were observed The results showed:in the high dose Ge 132 group,the
antitumor percentage was 31%,with
infiltrating WBC in the transplanted tumor tissue 72 7%,and SOD activity in serum 121Nu/ml Compared with the control group in which,the infiltrating WBC in the tumor tissue was 36 4%,and SOD activity in serum was 81Nu/ml,there existed significant difference (P<0 05) Meanwhile,in the CTX group, the anti tumor percentage was 37%,with infiltrating WBC 27 3% and SOD activity in serum 102Nu/ml. But in the high dose Ge 132 plus CTX group,the antitumor percentage was 45%,with infiltrating WBC 54 4% and SOD activity in serum 142 Nu/ml There also existed significant difference between the two groups(P<0 05) The results suggest that Ge 132 has the effect of antitumor and can enhance cellular immunity and SOD activity in serum on transplanted hepatocarcinoma bearing mice when applied in high dose CTX has strong antitumor effect but it lead to serious immunosupression When combined with high dose Ge 132 ,Ge 132 could relieve the immunosuppression and enhance the activity of SOD in serum and the anti hepatocarcinoma effect of CTX