The cardiovascular effects of different management of propofol were investigated in order to find a more proper scheme of anesthesia induction with propofol. 22 adult patients, ASA grade 2 or 3, were divided randomly into 2 groups after premedication, Group A( n =12) and group B( n =10). Method: Patients in group A received fentanyl (2 μg/kg,intravenously) beforehand, then infused with propofol at a rate of 40 mg per 10 seconds ,paused for 10 seconds when the proposal dosage reached 1 5 mg/kg. If patients eyelash reflex disappeared, gave muscle relaxant, if not, continued to give propofol at a rate of 20 mg per 10 seconds until patients eyelash reflex disappeared. Then, gave succinylcholine(2 mg/kg)to carry out endotracheal intubation. Patients in group B were infused with proposal at a rate of 40 mg per 10 seconds until the disappearing of eyelash reflex and infused with succinylcholing(2 mg/kg) to finish endotracheal intubation. Endotracheal intubation was carried out 2 minutes after the infusion of proposal in all groups.HR, SBP, MAP and DBP were continuously observed and were respectively recorded at the time of preinduction(T 0), 1 min(T 1) and 2 min (T 2) after the infusion of propofol, the moment of endotracheal intubation(T 3) and 3 min after intubation(T 4), RPP (rate pressure product) was calculated to indirectly reflect heart oxygen consumption.
Result: HR, SBP, MAP, DBP and RPP did not significantly changed after induction in group A.However, HR gradually increased in group B after induction, and significantly higher than its preinduction value( P <0 05). Also, the RPP values at T 3 and T 4 were both higher than its T 0 value ( P <0 01)in group B.Conclusion: Giving Fentanyl(2 μg/kg) in advance and then infusing propofol interruptedly at differtent rate can fully inhibit cardiovascular side effects of endotracheal intubation, reduce heart oxyen consumption and dont cause significant preintubation hypotension. Therefore, it is an ideal propofol induction method.