The effect of oral administration of
selenium(Se) on cadmium (Cd)-induced trace elements distribution in pregnant Wistar
rats was studied.18 pregnant rats on 0d of gestation were randamly divided into 3 groups: A:Cd toxication, B:Cd toxicater, +Se inhibition and C:control group. The rats in 3 groups were fed food and tap water, except that the rats of group B were fed water containing Se 4 μg/ml. The results showed: 1.In group A,the contents of copper(Cu)and Cd in blood, liver and kidney were increased, the contents of zinc (Zn)and Se decreased significantly (P<0. 01). The contents tents of
manganese(Mn)in blood were decreased and Mn in kidney were increased obviously. The contents of Mn in liver hadn't change significantly. 2. Oral administration of Se (group B)led to redistribution of trace elements in the body of rats. The contents ofCd in blood, liver and kidney in group B were remarkably lower than in group A (P< 0.01). The contents of Cu in blood were higher than in group A and C.The contents of Cu in liver and kidney were significantly lower in group B than in group A. The contents of Zn and Se in blood and liver were significantly increased in group B. The contents of Mn in blood were higher and contents of Mn in liver and kidney were lower than in group A (P<0. 01). The results indicate that oral administration of Se could decrease Cd accum-ulation in the body;Se also had remarkable antagonistic effect on the distribution change in Cd-induced of Cu, Zn, Mn, Se in the body of rats,which enabled the distribution of these trace elements to approach normal equilibrium.