To determine the
protective effects of Tong一Mai一Ling on
myocardial reperfusioninjury,24 hybrid dogs were
divided randomly into 4 groups ,the open一chest dogs were subject to leftanterior coronary
descending artery
occlusion for 60 min followed by 4 h reperfusion. Dogs were ran-domized
treated with Tong一Mai一Ling一l(TM,Tong一Mai一Ling一2(TM2),Dan一Shen(DS)and norn1al
saline(NS)at 0.5h of occlusion,Cardiac
function and hemodvnamic variables were measured
before occlusion 60 min after occlusion,and l h,2h,4h after reperfusion.
Cardiac output(CO),cardiac index(CI),left ventricle work index(LVWI ) ,heart stroke index(SI ),±
dp/dtmaxand leftventricular pressure(LVSP)markedly decreased ,while total peripheral vascular
resistance(TPVR )and left ventricular endodiastolic pressure(LVEDP)increased with the
development of occlusion一reperfusion in NS group.TM1,TM2 and DS increased the mean
blood pressure(MBP ),CO , CI ,SI,LVWI , LVSP and±dp/dtmax,while decreased TPVR,LVEDP
after occlusion一reperfusion in com-parison with NS group. These results suggested that TML
reduced myocardial ischemic reperfusion in-jury with salvage of myocardium,improved cardiac
function and some indexes of hemodynamics signif-icantly ,and prevented heart from
myocardial ischemia。
More abstracts about the Effects of Tong一Mai一Ling on cardiac function and hemodynamics of myocardial reperfusion
injury