Workers and 18 volunteers exposed to
toluene were studied. Toluene
concentrations in the
exhale air during the exposure varied apparently. The declining of toluene concentrations in exhale air samples after the end of wornkshift fitted a two-compartment
kinetics model consisting of fast phase with half time of 4-5 minutes and slow phase 2-2.5 hours.The statistics momental analysis
method was applied to compare with the traditional compartment model. with simple calculation procedure and results easy to explain,statistics momental analysis method has potential toxicological significance in kinetics study. The mean residual times(MRT) of toluene in exposed workers were 162-225 minutes that directly reflected the excretion of toluene of human body. To establish kinetics equations of particular concenttration, linear regressional method was used to estimate intercept of Yaxis(A,B values). The TWA air concentrations were significantly correlated with the A,B values(r=0.043-0.92,p<0.05). From kinetics equations it is suggested that the occupational exposure biological limit
values (OBELV) of exhale air concentration for toluene exposure to 100mg/m3(TWA-8h) be 70, 20, 10 and 0.36mg/m3 in the samples taken from 0,30 and 180 minutes since the cessation of exposure and the morning after the workshift respectively.
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