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Shvoong Home>Medicine & Health>Cycloheximide and Naloxone Affect the GnRH-Pituitary Priming Effect induced by Steroidal Contracepti Review

Cycloheximide and Naloxone Affect the GnRH-Pituitary Priming Effect induced by Steroidal Contracepti

Article Review   by:TsingHua     Original Author: REPRODUCTION AND CONTRACEPTION
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The model for priming effect of GnRH in proestrous rat has been used for this study.The results showed that stimulation of POA could induce more LH release in#53(Anordrin) treatedgroup than in control group(P<0.05),but significantly inhibit LH release to much lower level inLNG (Levonorgestrel) group than that in control group.It is obvious that the key position foraugmentation or inhibition of LH release by these two drugs is in the anterior pituitary. Intravenous injection of cycloheximide 100μg/100g b. w. to rats pre-treated with steroidal contraceptives,the LH release in # 53+cycloheximide group or cycloheximide group showed lower thanthat in control group (P<0.01),but the # 53+ cycloheximide group had relatively more LH release than that in cycloheximide group(P<0.05).As comparing the cycloheximide group withLNG+cycloheximide group,the former would gain more LH release,but there was no statisticalsignificance.In case of intravenous injection of naloxone 0.25mg/100g b.w.)to the rats pretreated with LNG,the result showed that naloxone could reverse the inhibitory effect of LNG.From the result mentioned above the augmentation of LH release under the certain dosage of # 53treatment is not due to the increase output of GnRH, but mainly through the enhancement of protein synthesis.For LNG action,it does not influence the pathway of protein synthesis but interferes the opioid receptor related route.
Published: April 30, 1995   
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