The effects of many usual
penetration enhancers such as azone(AZ) ,oleic acid(OA),poloxamer
188(POL 188)and propylene glycol(PG)on the blood
glucose level in
diabeticrats after transdermal
iontophoresis of
insulin were studied.
The change of blood glucose level(D%),defined as the percent ratio of
the concentration of blood glucose in
rats after the
iontophoreticapplication of insulin to that before administration of
insulin, was used to present the data. The resultsshowed that
following iontophoretic application of insulin for 3 h, the D%in
diabetic rats treated with100%AZ and 5%AZ/PG was 38.58%and
25.28%respectively, and the D%in diabetic ratsuntreated with
enhancers was 45.48%.The D%in diabetic rats treated with
100%OA,10%OA/PG,10%POL 188/PG and 10O%PG was 66.28%, 60.47%,
76.75%and 57.93%respectively.So,AZ showed a synergistic
effect on the
ability of iontophoresis to promote skinpermeation of insulin, and PG
further increased this effect.The combination of AZ, PG
andiontophoresis increased the permeation of insulin
significantly.OA,POL 188 and PG did not displaysynergistic effect on
iontophoresis enhancement.The combination of iontophoresis and some
enhancersprovided a novel idea and possibility for the administration
of polypeptide drugs.
More abstracts about the TRANSDERMAL IONTOPORESIS OF INSULIN:EFFECT OF PENETRATION ENHANCERS
ON BLOOD GLUCOSE LEVEL IN D