Objective : This study was undertaken for the prevention of
postmenopausal osteoporosis and itstreatment with combined Chinese
and Western medicine。 Methods : Thirty-four 6 month old female Wisterrats were divided randomly into four groups : 9 in the sham-OVX; 9 in the OVX + NS;7 in the OVX + DES(0. 0375 g/L)and 9 in the OVX + JRT( 1 tablet/ml). Demineralized bonematrices made, by using Uristmethod, from the femora and the tibiae of the same species of animal, were planted into the rats during theovariectomy. The medication to the four groups, as indicated above, began on the 3rd day after OVX andlasted for 6 weeks。 The labels of tetracycline were made on the 23rd and 30th day。 All rats were killed 6weeks after the operation, The right femora and the planted decalcified bones were processed undercalcifiedfor quantitative bone histomorphometry。 Results : In the OVX + NS group the mean wall thicknesses, themean trabecular widths, the bone cell lacunals lengths and widths all significantly reduced and the serum al-kaline phosphatose rose。 These were similar to the changes of
osteoporosis in
postmenopausal women。 More-over, in decalcified bone the mean mineralization deposition rats, the mineralization lag time and amount ofinduced bone were significantly lower than those in sham-OVX group. After treatment with DEX or JRT,the above indexed were increased remarkably。 Conclusions : It is suggested that JRT or DES can prevent thebone loss and increase the mineralization of bone in OVX rats by recovering the balance of bone remodeling。They can be used to prevent postmenopausal osteoporosis。