Treatment of left ventricular dysfunction(LVD)precipitated by myocardial ischemia remains a major therapeutic challenge.To
evaluate the effect of fructose 1,
6-diphosphate(FDP)on LVD and on the ischemic myocardial ion levels,a LVD model was established by occlusion of the left anterior descending and left circumflex coronary arteries in dogs. After succeeded in making the LVD model, FDP was administered (iv),1.0 g in the first two minutes , and 1.5 mg/kg/min for 3 hours. The control dogs (n= 8)were given normal saline (iv). During drug administration,hemodynamic parameters were recorded. At the end of experiment,K+,Na+,Ca(2+),Mg(2+),Cu(2+),Zn(2+),Fe(2+) ,Mn(2+) and Se(2-)
concentrations of the ischemic and the non-ischemic left ventricles were determined. LVEDP decreased , CO increased,and mean pulmonary arterial pressure decreased significantly during FDP administratiun. In the control dogs, K+ and Mg(2+) concentrations reduced by 44% (p<0.01) and 26% (p<0.01),Na+,Ca(2+),Fe(2+)and Se(2-)increased by 78% (p<0.01),61% (p<0.01),39% (p<0.01), 79% (p<0.01) and 61% (p<0.01),respectively,in the ischemic myocardium. After FDP treatment, however,changes of the above ion concentrations in the ischemic myocardium was significantly alleviated. The present study suggests that FDP could not only improve hemodynamic parameters, but also prevent ion metabolism abnormality in the ischemic myocardium during ischemic LVD.