This paper is aimed at investigating the effect of various doses of Se on Cd-
induced fetal malformation, toxicity of
maternal
rats and the distribution of Cd in their bodies. 28
maternal rats of pregnancy were divided randomly into 5 groups. A group with toxication was injected with 2mg/kg Cd three times on day 7,9,11 of gestation and given tap water. B,C and D groups were fed water containing Se 16μg/ml, 8μg/ml 4μg/ml respectively.Injection were given with 2mg/kg Cd 3 times to B, C and D groups on day 7, 9, 11 of pregnancy. E group(control group) was given tap water and injected with saline solution.Those rats in 5 groups were killed on day 20 of gestation, abdomens were cup open, the number of living fetus, dead fetus,fetal malformation and resorbed embryo were recorded. The living fetus were weighted and maternal blood, liver and kidney were taken out and kept in refrigerator at-20℃ for examining their contents of Se and Cd later.The results show 1. D group had much more inhibiting effect on Cd
induced toxicity of embryo than B and C group. The rate of resorbed embryo rose and the average weight of living fetus decreased with increase of the doses of Se. 2. D group had remarkable inhibiting effect on the growth ofCd-induced maternal rats. 3. There exists antagonism in the body betweenSe and Cd.