This text is a report on the results of the effects of PSP on the immunology of the norinal animals ,the tumor-bearing animals
and the animals administered with chemotherapy and radiotherapy.Oral administration or abdominal injection of PSP(0. 5～2.0g/kg×9 or 200-400mg/kg ×4)can appreciably raise the mice' s clearance rate of the Indian ink (P<0. 01). Its function is similar to that of acanthopanax.The oral administration of 1. 5g/kg×5 of PSP can make mice produce an amount of IL-2 twice as high as that of physiological saline group (P<0. 01). Under the presence of Con A , the application of 100-800ng/mL cell cultivation solution of PSP can increase the T lymphocytes of the spleens by 1. 5 to 4 times. With the application of cell cultivation solution of PSP (100-1000mg/mL)to cultivate the WBC of human blood,the amount of a or γ interferon induced will be 2 to 4 times as high as that of the control group. The application fo PSP to mice injected with cyclophosphamide will have different degrees of increase of their numbers of WBC. The numbers of WBC of the oral administration group(2. 25～4.00g/kg×8)will rise from 41,000～69,000 up to 74,000/mm3 and those of the abdominal injection (200～400mg/kg)group will rise from 60, 000～80, 000 up to 86, 000/mm3. PSP can also remove the inhibitory effect of cy-clophosephamide on IL-2,making the amount of IL-2 of mice injected with cyclophosphamide rise from 1557 to 2374 cpm(P<0. 01). PSP has also the same effect on the delayed type of hypersensitive reaction (DTH). It can restore DTH reaction inhibited by cyclophosphamide. (P<0. 05)The application of PSP to sarcoma bearing mice can increase the weight of the thymus atrophied (P<0. 05) and can also increase the amount of antibody and complement C3of the sarcoma bearing mice (P<0. 01).