This paper presents the histology
and histochemical study of the liv-er cirrhosis of rats treated by PGR decoction (Paeonia rubra,
Garde-nia jasminoides, Rheum palmatum).Forty-eight wistar rats were divid-ed into three
groups.The liver cirrhosis group (14) was medicatedwith CCl4 and other compound factors(such
as high grease diet andalcohol drink),the treated group(20) was given PGR decoction
throughgastric intubation for forty-one days besides CCl4 and other compoundfactors, while the
control group(14)was administered with normal foodsand water only.From the experimental
result of the treated group displ-ayed the rate of liver cirrhosis was obviously decreased as
comparedwith the liver cirrhosis group(P<0.01).In hepatic lobule the ne-crotic area and the liver
cellular fat droplets decreased.And RNA,gly-cogen, nucleolus increased,and SDH,G-6-Pase
activity increased aswell. According to this observation, it is suggested that the PGR decoc-tion
available can decrease liver cirrhosis caused by CCl4 and other co-mpound factors.Its
machamism may be that the PGR decoction can pre-vent the damage of endoplasmic reticulum,
promote protein synth esisand detoxiation and decrease the damage of mitochondria.And the
heapof the liver cellular fat droplets decrease.Then the liver cellular nec-rosis and
inflammation reaction decrease too. Therefore the formationof fibrolast and collagenous fiber
is decreased, so the liver cirrhosiscan be prevented.