Aim: To observe the effects of recombinant bovine basic fibroblast growth factor (rbFGF) on acute and chronic wounds healing.
Methods: 1 282 cases with acute wounds such as burn, donor site or operative wounds and chronic wounds were treated with bFGF. Another 439 cases with the similar wounds were used as control. The complete healing time, healing rates and adverse reaction of wounds healing were observed. Results: In superficial Ⅱ degree burn wounds, the healing rate for 8 days post-burn and complete healing time was 51.7%±26.4% and (12.6±2.9)d (P<0.001)
respectively in control group and was 70.6%±25.0% and (10.5±2.4)d (P<0.001) respectively in trial group. In deep Ⅱ degree burn wounds, the healing rate for 15 days post-burn and complete healing time was 53.3%±25.4% and (21.9±5.5)d (P<0.001) respectively in control group and was 69.7%±27.0% and (18.5±4.4)d (P<0.001) respectively in trial group. In operative wounds, the healing rate for 8 days and complete healing time was 57.6%±29.4% and (11.4±2.7)d (P<0.001) respectively in control group, and was 72.1%±28.0% and (9.5±2.4)d (P<0.001) respectively in trial group. In chronic wounds, the complete healing time was (28.0±18)d in control group and (22.1±16.0)d in trial group (P=0.068). Conclusion: Recombinant bovine basic fibroblast growth factor (rbFGF) can improve the quality and the velocity of
wound healing significantly.