Aim
Nanoparticle study on monarch drug in the complex Huang Dai tablet-
realgar,laying the groundwork for deeply investigating realgar particle size effect induced by cellular apoptosis,mechanism of action and new pharmaceutical technology.Methods High-energy ball-milling on ZJM-20/25 ball mill.Surface active transformation by surface active mass,preventing
crystal form from transition and
decomposition by thermogravimetric analysis(TGA);particle size analysis by laser scattering,analysis on tape of typical
powders by scaning electron microscope(SEM) and transmission electron microscope.Results and Conclusion Decomposition temperatures of realgar in air and nitrogen are the same 260℃.In the high-energy ball-milling,realgar has not distinct crystal form transition and decomposition accept transformation towards non-crystal.With the time prolonged of ball-milling,the crystal particles of realgar powder rapidly transformed to nanoparticle level and there is the trend to non-crystal.In the water with active agent , ball mill can obtain masses with tiny uniform-distributed powders,the dispersion effect of sodium laurylsulfonate is better than that of sodium dodecyl sulfate. After this ball-milling,the powders at diameter 200nm reach above 85%,which are constituted of more tiny particles which are the tiny crystal particles below 20nm and non-crystal around it.