The goal of this study is that determining pharmacodynamics on the experimental imbalance of mouse
intestinal bacterial flora
and the curing efficiency of antibiotic related diarrhea of Spirulina by assaying its pharmacodynamics at different concentrations. This experimental results have showed that:1)All modeled mice performed diarrhea at middle or severe before therapy. And after treating all mice of middle and high Spirulina dosage treating groups and 80% of low Spirulina dosage treating group performed diarrhea at mild. 2)The number of Enterobacter and Bifidobacterium of low dosage Spirulina curing group was higher significantly than that of two controls ( P <0.05) at the early stage. The number of 5 types of
intestinal bacterial flora of high Spirulina dosage group was similar to that of middle dosage group, which was significantly higher than that of naturally restoring group ( P < 0.01 ) and physiological saline group ( P <0.05 or P <0.01). Therefore, we hold that Spirulina can attenuate diarrhea symptoms of mouse intestinal bacterial flora imbalance model, yet depending on dosage used. Middle and high Spirulina dosages can mitigate the symptoms of mouse diarrhea quickly, setting their intestinal bacterial flora in correct order. However, the middle and high dosages have similar contributions.