OBJECTIVE To explore the brain function improving mechanism of Jiawei Wendan (JWWD)
prescription. METHODS By using high
performance liquid chromatography to observe the change of 4 amino acids of SAM P/10′s brain, which had close relation with learning memory.RESULTS The Glu, Gln?Asp in cortex of preventive
prescription and prescription No. I decreased significantly( P < 0.01 ), as to prescription NO.II, only Asp decreased obviously( P < 0.05 ), all index of western medicine had no obvious reducing tendency. Asp in hippocampus of groups treated by Chinese medicine deceased significantly( P < 0.01 ), so did western medicine( P < 0.05 ), the level of Asn decreased after treatment, preventive prescription had no obvious difference from that of SAM R/1,the increasing of the other groups′Asn had obvious difference from that of SAM R/1( P < 0.01 ),the Asp, Asn in striate body for preventive prescription and prescription No 1 droped obviously ( P < 0.01 ), as to prescription No.Ⅱ, only Asp, Asn has obviousy reduced, furthermore, decreasing of Asn is very different from that of SAM R/1( P < 0.05 ). The increasing of Glu, Asp, Asn in striate body treated by western medicine increased obviously ( P < 0.01 ), Asp decreased obviously( P < 0.05 ), but not so much as Chinese medicine.CONCLUSIONS It prompts that Jiawai Wendan prescription can regulate the level of SAM P/10′s EAAs obviously. This provide bases for the clinical use of Jiawei Wendan prescription on the encephalic senility and senile dementia.