Objective:To explore the possible role of zhigantai(ZHGT)capsule in the therapy of fatty liver with
hyperlipidemia Methods:The
animal models with high fat diet were divided into model group,high dose group,low dose group,dongbao gantai(DBGT)group as well as control group and normal control group at random All the treatment groups were intervened by its own medicine,then detected glucagon contents in plasma,serum insulin contents and
free fatty acid(FFA)contents in serum,hepatic tissue Results:The glucagon contents in plasma and FFA contents in serum,hepatic tissue of model group were increased significantly(P<0 05 or P<0 01) The serum insulin contents were reduced remarkably than normal control group(P<0 01) Compared with model group,glucagon contents in plasma and FFA contents in serum,hepatic tissue of all the treatment groups were reduced remarkably(P<0 05 or P<0 01) The content of all the guideline in low dose group was lower than DBGT group(P<0 05) The serum insulin contents of all the treatment groups were increased significantly(P<0 01) The contents of high dose group and low dose group were higher than DBGT group(P<0 05) Conclusions:By reducing the content of glucagons and increasing the insulin and FFA contents,ZHGT capsule had the effect of resisting fatty liver